Bristol-Myers Squibb is leading the exploration of immune-biomarkers in Immuno-Oncology
Beyond PD-L1, new immune-biomarkers are now being investigated across tumor types. This exploration is focused both within the tumor microenvironment and in the periphery.1-12
within the tumor
TILs/immunoscore (eg, CD4 and CD8 T cells)
Gene expression signatures (immune signatures/inflamed phenotype)
Tumor immune marker expression
within the periphery
Immune-monitoring: absolute lymphocyte count, circulating T-cell subsets/MDSCs
Gene expression profiling:
interferons, interferon inducible factors, serum soluble factors
Bristol-Myers Squibb is researching the power of immune-biomarkers to help identify patients who are more likely to benefit from Immuno-Oncology therapies.
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