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This site is intended for US Health Care Professionals only.

Realizing the Potential of Immuno-Oncology Research

Depth of evidence for the immune response to cancer

Both solid tumors and hematologic malignancies are able to induce an immune response that can regulate their initial growth. This ability is known as tumor immunogenicity.1,2

Presentation

Traditionally, immunogenic tumors, including melanoma and non-small cell lung cancer (NSCLC), are defined by a high rate of mutations.3 These mutations create tumor antigens that can be recognized by the immune system, activating an antitumor immune response.4

 

Infiltration

Tumor-infiltrating immune cells are present in the tumor microenvironment.5-17 Their presence demonstrates their capacity to identify and migrate to tumor cells.18

 

elimination

Early in their development, some tumors display evidence of spontaneous regression. This suggests that the immune system is able to recognize and eliminate some tumor cells.19

This supports the concept that the body’s own immune system has the ability to induce an antitumor response against cancer.20 Research is actively underway as evidence suggests that targeting immune pathways may help in eliminating tumor cells.


Broad potential of Immuno-Oncology research

The immune system’s ability to detect and destroy tumor cells is the foundation of Immuno-Oncology research. Evidence for tumor immunogenicity across a wide range of solid tumors and hematologic malignancies provides the rationale for the breadth of Immuno-Oncology research across tumor types.21

Evidence for Tumor Immunogenicity
Tumor
Type
PRESENTATION
Presence of
somatic
mutations
INFILTRATION
Evidence of
immune-cell infiltration
ELIMINATION
Evidence of spontaneous regression
Bladder3,15  
Breast17,22  
Colorectal16  
Gastric/Esophageal8,23  
Glioblastoma4,6  
Head & neck9,24  
Hepatocellular13  
Lung3,8  
Melanoma3,8,19
Ovarian12,25  
Pancreatic16  
Prostate10,26 check check  
Renal3,11
Non-Hodgkin Lymphoma5,27 check  
Hodgkin Lymphoma14,28  
Leukemia29  
Multiple Myeloma7,30  

Bristol-Myers Squibb continues to investigate the expanding field of Immuno-Oncology research, driven by the many patients with advanced cancer who await the offer of renewed hope and the potential of a longer life.

References

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